L-Methylfolate (1mg) Plus Methyl-B12

The body-ready folate + B12 formula for mood, methylation, and brain health.

  1. No conversion required — 5-MTHF is immediately absorbed without the metabolic processing steps that synthetic folic acid demands*
  2. Supports mood, energy, and mental clarity — fuels neurotransmitter production for serotonin, dopamine, and norepinephrine*
  3. Paired with Methyl B12 for complete methylation support — L-Methylfolate can't do its job without B12 — both included at clinically validated doses*

1 fl oz · 300 Servings

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  • Absorbs directly into the bloodstream and requires no processing from the body.
  • Contains the essential Cofactor MethylB12.
  • Supports brain and heart health and contributes to balancing energy, hormones, and mood

L-Methylfolate is the biologically active, bloodstream-ready form of Folate (Vitamin B9). Our formulation provides a daily dose of 1 mg L-Methylfolate. This strength was formulated to support everyday Folate nutritional needs. The formula also includes a whole serving of Methyl-B12, an essential cofactor to L-Methylfolate. The liquid sublingual form provides enhanced absorption and an enjoyable cherry flavor. A daily dose of 1 mg of methylfolate plays a crucial role in supporting the healthy development of your baby during pregnancy. It also contributes to the production of neurotransmitters, which are involved in maintaining focus, regulating sleep patterns, providing energy, balancing hormones, and impacting mood. Furthermore, Methylfolate promotes heart health and optimal nerve function.*

  • Supports mood & cognition*
    Supports healthy methylation*
    Supports heart health*
    Supports nerve cognition*
  • Folate
  • Vitamin B12

Shake before use. Add 2 droplets on or under the tongue. Drops can also be added to water, juice, or smoothie.

Available strengths & formulations

  • Triquetra Kids L-Methylfolate liquid with 5-MTHF active folate and methyl B12 for brain development, mood and behavior support in children

    Kids Methylfolate Plus B12 Cofactor

    Supports nutritional needs of children
    $22.95 or $19.51/mo
  • Triquetra L-Methylfolate 1 mg capsules with 5-MTHF active folate and methyl B12 for methylation, brain, mood, heart and nerve support

    L-Methylfolate (1 mg) Plus Methyl B12 Capsules

    Active, bloodstream-ready folate with essential Methyl-B12 cofactor
    $17.99 or $15.29/mo
  • Triquetra L-Methylfolate 15 mg capsules with 5-MTHF active folate and methyl B12 for methylation, brain, mood, heart and nerve support

    L-Methylfolate (15 mg) Plus Methyl B12 Capsules

    Professional-strength active folate with essential Methyl-B12 cofactor
    $22.99 or $19.54/mo
  • Triquetra L-Methylfolate 15 mg liquid drops with 5-MTHF active folate and methyl B12 for methylation, brain, mood, heart and nerve support

    L-Methylfolate (15 mg) Plus Methyl-B12

    Active, bloodstream-ready folate with essential Methyl-B12 cofactor
    $22.99 or $19.54/mo
  • Triquetra L-Methylfolate 1 mg liquid drops with 5-MTHF active folate and methyl B12 for methylation, brain, mood, heart and nerve support

    L-Methylfolate (1mg) Plus Methyl-B12

    Active, bloodstream-ready folate with essential Methyl-B12 cofactor
    $23.99 or $20.39/mo
  • Triquetra L-Methylfolate 7.5 mg capsules with 5-MTHF active folate and methyl B12 for methylation, brain, mood, heart and nerve support

    L-Methylfolate (7.5 mg) Plus Methyl B12 Capsules

    Active, bloodstream-ready folate with its essential Methyl-B12 cofactor
    $18.99 or $16.14/mo
  • Triquetra L-Methylfolate 5-MTHF liquid drops with methyl B12 providing 7.5 mg active folate for methylation, mood, brain and heart support

    L-Methylfolate (7.5mg) Plus Methyl-B12

    Active, bloodstream-ready folate with essential Methyl-B12 cofactor
    $17.99 or $15.29/mo

See how L-Methylfolate helped others

Healthy methylation plays a role in many everyday functions:

Mental
clarity*

Emotional
balance*

Cellular energy
production*

Healthy
hair*

Skin
health*

Energy
metabolism*

Emotional
well-being*

Stress
response*

Supports
heart health*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

How L-Methylfolate works in the body

  • Supports neurotransmitters like serotonin, dopamine & norepinephrine.*
  • Supports red blood cells production and detox in the body.*
  • Helps your homocysteine levels stay in check which is vital for heart and brain health.*

Methylated Folate: A Nutrient Form Some People Prefer for Genetic Support*

Certain MTHFR gene variations may reduce how efficiently the body converts synthetic folic acid.* Methylated forms like 5-MTHF can offer a more direct form of folate support.

Methylated vitamins provide folate in a body-ready form, supporting bioavailability and cellular use.*

Results Over Time

  • Days 3-7

    Gradual support*

    Some individuals may begin to notice support for mental clarity, mood balance, and energy. This is also when nutritional support for red blood cell formation and homocysteine metabolism may begin.*

  • Weeks 2-4

    Noticeable support*

    Neurotransmitter production for the ‘feel good’ hormones like serotonin & dopamine goes up which can help with an improvement in mood and a reduction in symptoms of anxiety.*

  • Months 3-6

    Ongoing support*

    Some individuals may notice more consistent energy levels and support for healthy eating patterns. Users have also shared feeling more in tune with their overall wellness goals and daily routines.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Hear From Our Experts

"As a health researcher, I view L-Methylfolate as an essential nutrient for neurological, emotional, and metabolic balance—especially in individuals with genetic variants like MTHFR. Triquetra’s L-Methylfolate line stands out for its clinically relevant dosing, exceptional purity, and highly bioavailable formulas, with options tailored for both adults and children. It’s a science-backed choice for those seeking therapeutic efficacy and uncompromising quality."

- Adriano Zanardi da Silva, M.Sc., Ph.D

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

 How to take L-Methyfolate

1. Shake well before use.

2. Take 2 droplets directly under tongue OR mix 2 droplets into your favorite drinks, smoothies or water.

Which dose is right for you?

  • 1mg light supplementation

    Starting dose for general wellness or anyone new to methylated folate

  • 7.5mg moderate supplementation

    For those supporting folate metabolism and cellular function at a higher level*

  • 15mg high therapeutic use

    For advanced nutritional needs or personalized wellness goals under healthcare guidance*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Standards Without Compromise

This formula is crafted with thoughtfully selected ingredients and manufactured to rigorous quality standards.

GMO
Free

Vegan

Gluten
Free

Thoughtfully formulated. Independently tested.

We prioritize transparent sourcing, thoughtful formulation, and third-party testing standards to help ensure quality, purity, and consistency across our products.

  • Third-Party Tested

    Third-Party Tested

    Products are independently tested to verify quality, purity, potency, and ingredient standards.

  • Thoughtfully Sourced Ingredients

    Thoughtfully Sourced Ingredients

    We partner with trusted suppliers to select premium ingredients backed by research and rigorous quality standards.

  • Intentional Formulations

    Intentional Formulations

    Every formula is designed for ingredient compatibility, bioavailability, and effective dosing.

  • GMP-Certified Manufacturing

    GMP-Certified Manufacturing

    Manufactured in GMP-certified facilities that follow established quality control standards.

Third-Party Tested
GMP-Certified Facility
Transparent Sourcing
Practitioner-Informed
Quality-Focused

Frequently asked questions

L-Methylfolate is the active form of folate that your body can use immediately. Folic acid needs to be converted—and some people can’t do that well because of genetic mutations like MTHFR.

Methyl B12 (aka Methylcobalamin) is a highly bioavailable form of B12 that works synergistically with L-Methylfolate to support brain health, energy, and mood.

Check with your doctor first. L-Methylfolate is often recommended during pregnancy, but always confirm with your healthcare provider.

It is possible L-Methylfolate may interact with certain medications. It is always best to check with a healthcare provider before starting any supplements.

Most people tolerate it well. If you feel like you are sensitive to higher doses, you can work your way up to the full dose over time.

It can be taken with or without food, but some people prefer it with a meal to avoid mild stomach discomfort.

Build Your Complete Routine

Warning: If you have a medical condition or are taking medication, contact a physician before taking this supplement. Keep out of reach of children. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

To report a serious adverse event, please contact 844-272-6337.