Triquetra L-Methylfolate 5-MTHF liquid drops with methyl B12 providing 7.5 mg active folate for methylation, mood, brain and heart support
Person using Triquetra L-Methylfolate 5-MTHF liquid drops with methyl B12, an active folate supplement in sublingual form for methylation support
Triquetra L-Methylfolate 5-MTHF liquid drops showing 7.5 mg L-methylfolate and 750 mcg methyl B12 supporting optimal folate levels and methylation
Triquetra L-Methylfolate 5-MTHF liquid supplement with methyl B12 showing the metabolically active form of folate for methylation and cellular support
Supplement facts panel for Triquetra L-Methylfolate 5-MTHF liquid drops showing 7.5 mg L-methylfolate and 750 mcg methyl B12 with suggested use and quality standards
    Triquetra L-Methylfolate 5-MTHF liquid drops with methyl B12 providing 7.5 mg active folate for methylation, mood, brain and heart support
    Person using Triquetra L-Methylfolate 5-MTHF liquid drops with methyl B12, an active folate supplement in sublingual form for methylation support
    Triquetra L-Methylfolate 5-MTHF liquid drops showing 7.5 mg L-methylfolate and 750 mcg methyl B12 supporting optimal folate levels and methylation
    Triquetra L-Methylfolate 5-MTHF liquid supplement with methyl B12 showing the metabolically active form of folate for methylation and cellular support
    Supplement facts panel for Triquetra L-Methylfolate 5-MTHF liquid drops showing 7.5 mg L-methylfolate and 750 mcg methyl B12 with suggested use and quality standards
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    L-Methylfolate (7.5mg) Plus Methyl-B12

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    Key Ingredients

    • Folate

    • Vitamin B12

    Size / Suggested Use

    • Size: 120 servings - Berry Flavor

    Product Details

    • L-Methylfolate provides a potent, bloodstream-ready dose of 7.5mg of the most active form of Folate in the 5-MTHF calcium salt form.
    • Created with Methylcobalamin B12 to help support heart health and nerve function by regulating healthy homocysteine levels and nitric oxide production.
    • A powerful and reliable supplement to improve your mood, energy, concentration, and sleep.
    Our professional strength L-Methylfolate and Methyl B12, is a methylation support product designed based on clinical research. Each dose provides 7.5mg L-Methylfolate in the 5-MTHF calcium salt form plus 750 mcg of Methyl B12. L-Methylfolate is the active form of Folate and is bloodstream ready. This formulation was designed to support health methylation, mood, and brain health.

    Supplement Facts

    L_meth_7_5mcg_liquid_spp_facts
    Healthy methylation plays a role in many everyday functions:
    methyl_supports
    *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
    methyl_dna-min
    Methylated Folate: A Nutrient Form Some People Prefer for Genetic Support*
    Certain MTHFR gene variations may affect how the body processes synthetic folic acid. Methylated forms like 5-MTHF can offer a more direct form of folate support.

    Methylated vitamins provide folate in a body-ready form, supporting bioavailability and cellular use.*
    methyl_group
    Up to 40% of people may carry a common MTHFR gene variant.* 

    Why You’ll Love Our L-Methylfolate

    methyl_liq7-5mgbot
    methyl_liq15mg_shadow
    Bloodstream Ready L-Methylfolate*
    Designed for Efficient Absorption*
    No Conversion Required - Body-Ready Form*
    Enhanced with B12*

    How L-Methylfolate Works in the Body

    Supports neurotransmitters like serotonin, dopamine & norepinephrine.*
    Supports red blood cells production and detox in the body.*
    Helps your homocysteine levels stay in check which is vital for heart and brain health.*

    Body-Ready Nutrients in One Easy Dose

    methyl_liqbotdropper-min
    Supports Mood & Cognition*
    Supports Healthy Methylation*
    Supports Heart Health*
    Supports Nerve Cognition*
    *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

    See how L-Methylfolate Helped Others!

    * These testimonials represent individual experiences. Participants received free product samples and were compensated for their time, but their opinions are entirely their own and were not influenced by our team. Individual results may vary. 

    How to Take L-Methyfolate

    1. Shake well before use.
    2. Take 5 droplets directly under tongue 
    OR mix 5 droplets into your favorite drinks, smoothies or water.
    mixed_drinks
    naturalBerry
    Know your supplement
    Our drops are a deep, rich burgundy shade. Please be cautious of counterfeit products that may differ in color or quality. To ensure you receive a genuine product, only purchase from our official websites or stores.

    Which dose is right for you?

    methyl_1mgpack
    1 mg Light 
    Supplementation 
    Best For: This is a starting dose for general wellness or individuals who want to support methylation.
    Learn More
    methyl_7
    7.5 mg Moderate Supplementation 
    Best For: Individuals seeking a higher level of methylated folate to support folate metabolism and cellular function.*
    Learn More
    methyl_15mgpack
    15 mg High
    Supplementation
    Best For: Those looking for a higher dose of folate to support advanced nutritional needs or personalized wellness goals, as recommended by a healthcare professional.*
    Learn More
    Genetic Wellness Support Starts Early
    Daily Nutritional Folate support with 
    KIDS L-Methylfolate
    Shop Now
    Results Over Time
    methyl_days3-7

    3-7 Days: Gradual Support*

    Some individuals may begin to notice support for mental clarity, mood balance, and energy. This is also when nutritional support for red blood cell formation and homocysteine metabolism may begin.*
    methyl_week2-4

    Weeks 4-8: Noticeable Support*

    Neurotransmitter production for the ‘feel good’ hormones like serotonin & dopamine goes up which can help with an improvement in mood and a reduction in symptoms of anxiety.*
    methyl_months3-6

    Month 3-6: Ongoing Support*

    Some individuals may notice more consistent energy levels and support for healthy eating patterns. Users have also shared feeling more in tune with their overall wellness goals and daily routines.*
    Disclaimer: Individual results vary. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

    Hear From Our Experts

    "As a health researcher, I view L-Methylfolate as an essential nutrient for neurological, emotional, and metabolic balance—especially in individuals with genetic variants like MTHFR. Triquetra’s L-Methylfolate line stands out for its clinically relevant dosing, exceptional purity, and highly bioavailable formulas, with options tailored for both adults and children. It’s a science-backed choice for those seeking therapeutic efficacy and uncompromising quality."
    Adriano Zanardi da Silva, M.Sc., Ph.D
    22

    Quality Standards You Can Trust

    methyl_qs2
    Warning: If you have a medical condition or are taking medication, contact a physician before taking this supplement. Keep out of reach of children.
    *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
    To report a serious adverse event, please contact 844-272-6337.
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    Triquetra L-Methylfolate 15 mg liquid drops with 5-MTHF active folate and methyl B12 for methylation, brain, mood, heart and nerve supportMan using Triquetra L-Methylfolate 15 mg liquid drops with 5-MTHF active folate and methyl B12 sublingual methylation support supplement

    L-Methylfolate (15 mg) Plus Methyl-B12

    $22.49
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    Triquetra L-Methylfolate 15 mg capsules with 5-MTHF active folate and methyl B12 for methylation, brain, mood, heart and nerve supportWoman holding Triquetra L-Methylfolate 15 mg capsules with 5-MTHF folate and methyl B12 for methylation and cellular health support

    L-Methylfolate (15 mg) Plus Methyl B12 Capsules

    $22.49
    • 1-Bottle
    • 2-Bottles
    • 3-Bottles
    • 6-Bottles
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    • Berry Flavor
    • Flavorless
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    • 6-pack

    Frequently Asked Questions

    What is L-Methylfolate and how is it different from folic acid?

    L-Methylfolate is the active form of folate that your body can use immediately. Folic acid needs to be converted—and some people can’t do that well because of genetic mutations like MTHFR.

    What is Methyl B12 and why is it paired with L-Methylfolate?

    Methyl B12 (aka Methylcobalamin) is a highly bioavailable form of B12 that works synergistically with L-Methylfolate to support brain health, energy, and mood.

    Is this product safe if I’m pregnant or breastfeeding?

    Check with your doctor first. L-Methylfolate is often recommended during pregnancy, but always confirm with your healthcare provider.

    Can this supplement interact with medications?

    It is possible L-Methylfolate may interact with certain medications. It is always best to check with a healthcare provider before starting any supplements.

    Are there any known side effects?

    Most people tolerate it well. If you feel like you are sensitive to higher doses, you can work your way up to the full dose over time.

    How do I take it — with food or without?

    It can be taken with or without food, but some people prefer it with a meal to avoid mild stomach discomfort.

    Customer Reviews

    Based on 22 reviews
    82%
    (18)
    14%
    (3)
    5%
    (1)
    0%
    (0)
    0%
    (0)
    100.0
    83.3
    J
    Joan J.
    Great stuff

    I started slow, on drop until I got up to five.
    I feel more energy and I do have MTHFR C677T. Heterogeneous so one of the best not combo from mother and the father.
    Mother only. Private tested at own cost as dr will not order the test. I knew I had it. I had high MCV on my CBC.
    I have Hashimoto and secondary polycythemia.
    Thanks for the good product.
    My folste was a bit low dr suggested greens. I have IBS, greens not a good thing for everyday use.
    Again, waiting for blood work in two weeks.
    Joan

    P
    Patti Z.
    Love this product

    Works for me!

    C
    Cheryl M.
    It’s working

    We are pleased so far with some improvements

    m
    mark e.

    L-Methylfolate (7.5mg) Plus Methyl-B12

    D
    Desiree

    So far i really like the product.

    123