L-Methylfolate (7.5mg) Plus Methyl-B12
The body-ready folate + B12 formula for mood, methylation, and brain health.
- No conversion required — 5-MTHF is immediately absorbed without the metabolic processing steps that synthetic folic acid demands*
- Supports mood, energy, and mental clarity — fuels neurotransmitter production for serotonin, dopamine, and norepinephrine*
- Paired with Methyl B12 for complete methylation support — L-Methylfolate can't do its job without B12*
1 fl. oz. · 120 Servings
Supplement Facts
- Folate
- Vitamin B12
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HSA/FSA Eligible
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L-Methylfolate (7.5mg) Plus Methyl-B12
HSA/FSA Eligible
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Third-party tested
Thoughtfully formulated
Clinically studied ingredients
30-day satisfaction guaranteed
Free US shipping on orders over $75
- L-Methylfolate provides a potent, bloodstream-ready dose of 7.5mg of the most active form of Folate in the 5-MTHF calcium salt form.
- Created with Methylcobalamin B12 to help support heart health and nerve function by regulating healthy homocysteine levels and nitric oxide production.
- A powerful and reliable supplement to improve your mood, energy, concentration, and sleep.
Our professional strength L-Methylfolate and Methyl B12, is a methylation support product designed based on clinical research. Each dose provides 7.5mg L-Methylfolate in the 5-MTHF calcium salt form plus 750 mcg of Methyl B12. L-Methylfolate is the active form of Folate and is bloodstream ready. This formulation was designed to support health methylation, mood, and brain health.
- Supports mood & cognition*
- Supports healthy methylation*
- Supports heart health*
- Supports nerve cognition*
- Folate
- Vitamin B12
Shake before use. Add 5 droplets on or under the tongue. Drops can be added to water, juice or smoothie.
Pairs with
Healthy methylation plays a role in many everyday functions:
Mental
clarity*
Emotional
balance*
Cellular energy
production*
Healthy
hair*
Skin
health*
Energy
metabolism*
Emotional
well-being*
Stress
response*
Supports
heart health*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
How L-Methylfolate works in the body
-
Supports neurotransmitters like serotonin, dopamine & norepinephrine.*
-
Supports red blood cells production and detox in the body.*
-
Helps your homocysteine levels stay in check which is vital for heart and brain health.*
Methylated Folate: A Nutrient Form Some People Prefer for Genetic Support*
Certain MTHFR gene variations may reduce how efficiently the body converts synthetic folic acid.* Methylated forms like 5-MTHF can offer a more direct form of folate support.
Methylated vitamins provide folate in a body-ready form, supporting bioavailability and cellular use.*
Results Over Time
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Hear From Our Experts
"As a health researcher, I view L-Methylfolate as an essential nutrient for neurological, emotional, and metabolic balance—especially in individuals with genetic variants like MTHFR. Triquetra’s L-Methylfolate line stands out for its clinically relevant dosing, exceptional purity, and highly bioavailable formulas, with options tailored for both adults and children. It’s a science-backed choice for those seeking therapeutic efficacy and uncompromising quality."
- Adriano Zanardi da Silva, M.Sc., Ph.D
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
How To Take L-Methyfolate
1. Shake well before use.
2. Take 2 droplets directly under tongue OR mix 2 droplets into your favorite drinks, smoothies or water.
Which dose is right for you?
1mg light supplementation
Starting dose for general wellness or anyone new to methylated folate
7.5mg moderate supplementation
For those supporting folate metabolism and cellular function at a higher level*
15mg high therapeutic use
For advanced nutritional needs or personalized wellness goals under healthcare guidance*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Standards Without Compromise
This formula is crafted with thoughtfully selected ingredients and manufactured to rigorous quality standards.
GMO
free
Vegan
Gluten
Free
Thoughtfully formulated. Independently Tested.
We prioritize transparent sourcing, thoughtful formulation, and third-party testing standards to help ensure quality, purity, and consistency across our products.
Third-party tested
Products are tested for quality, purity, and ingredient standards.
Thoughtfully sourced ingredients
We prioritize carefully sourced ingredients selected for quality, compatibility, and formulation integrity.
Formulation standards
Products are developed with careful attention to ingredient quality, compatibility, and formulation integrity.
Manufactured with quality standards
Produced in GMP-certified facilities with established manufacturing and quality control standards.
Third-party tested
GMP-certified facility
Transparent sourcing
Practitioner-informed
Quality focused
Frequently asked questions
L-Methylfolate is the active form of folate that your body can use immediately. Folic acid needs to be converted—and some people can’t do that well because of genetic mutations like MTHFR.
Methyl B12 (aka Methylcobalamin) is a highly bioavailable form of B12 that works synergistically with L-Methylfolate to support brain health, energy, and mood.
Check with your doctor first.
It is possible L-Methylfolate may interact with certain medications. It is always best to check with a healthcare provider before starting any supplements.
Most people tolerate it well. If you feel like you are sensitive to higher doses, you can work your way up to the full dose over time.
It can be taken with or without food, but some people prefer it with a meal to avoid mild stomach discomfort.
Build Your Complete Routine
Warning: If you have a medical condition or are taking medication, contact a physician before taking this supplement. Keep out of reach of children. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
To report a serious adverse event, please contact 844-272-6337.
