Experience the powerful and transformative effects of our best-selling supplements, crafted with premium ingredients that have led to over a million bottles sold. Feel the difference.
This is based on the belief that we come from nature. We are not separate from it; within nature is all the abundant bounty we need to achieve optimal health.
Experience the powerful and transformative effects of our best-selling supplements, crafted with premium ingredients that have led to over a million bottles sold. Feel the difference.
This is based on the belief that we come from nature. We are not separate from it; within nature is all the abundant bounty we need to achieve optimal health.
Traditional Folic Acid Supplement Don’t Work with MTHFR Genes
MTHFR mutations block absorption of folic acid which is why traditional folic acid may not be working for you.
You can skip the long breakdown processes in the body by using methylated vitamins. These will absorb quickly and give you the benefits faster.
40% of Americans Have an MTHFR Gene Mutation
How L-Methylfolate Works in the Body
Supports neurotransmitters like serotonin, dopamine & norepinephrine.
Supports red blood cells production and detox in the body.
Helps your homocysteine levels stay in check which is vital for heart and brain health.
Reasons to Love Our L-Methylfolate
Immediate Absorption
No Breakdown Needed
Enhanced with B12
Clinically Validated Doses
15mg L-Methylfolate
L-Methylfolate is the active & bloodstream ready form of Folate (B9) immediately absorbed into the bloodstream without requiring processing by the body.
1000mcg Methyl B12
L-Methyfolate cannot do its job in the body without Methyl B12. If L-Methyfolate is the fire, think of Methyl B12 as the firewood.
See how L-Methylfolate Helped Others!
Methylfolate
** These testimonials represent individual experiences. Participants received free product samples and were compensated for their time, but their opinions are entirely their own and were not influenced by our team. Individual results may vary.
How to Use L-Methyfolate
Supports Mood & Cognition*
Supports Healthy Methylation*
Supports Heart Health*
Supports Nerve Cognition*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Which dose is right for you?
1 mg Light
Supplementation
Best For: This is a starting dose for general wellness or individuals who want to support methylation.
Expect to feel more mental clarity, a lift in mood, energy and less brain fog. This is also when your red blood cell production ramps up and your homocysteine levels begin to stabilize.
Weeks 4-8: Noticeable Progress
With regular use, neurotransmitter production for the ‘feel good’ hormones like serotonin & dopamine goes up which can help with an improvement in mood and a reduction in symptoms of anxiety.
Month 3-6: Ongoing Support
You may experience more steady energy, fewer energy crashes, and continued improvements in appetite control. Some users report feeling more in tune with natural hunger cues and more empowered in making healthy food choices.
Disclaimer: Individual results vary. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
"As a health researcher, I view L-Methylfolate as an essential nutrient for neurological, emotional, and metabolic balance—especially in individuals with genetic variants like MTHFR. Triquetra’s L-Methylfolate line stands out for its clinically relevant dosing, exceptional purity, and highly bioavailable formulas, with options tailored for both adults and children. It’s a science-backed choice for those seeking therapeutic efficacy and uncompromising quality."
Adriano Zanardi da Silva, M.Sc., Ph.D
Quality Standards You Can Trust
Warning: If you have a medical condition or are taking medication, contact a physician before taking this supplement. Keep out of reach of children.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
To report a serious adverse event, please contact 844-272-6337.
What is L-Methylfolate and how is it different from folic acid?
L-Methylfolate is the active form of folate that your body can use immediately. Folic acid needs to be converted—and some people can’t do that well because of genetic mutations like MTHFR.
What is Methyl B12 and why is it paired with L-Methylfolate?
Methyl B12 (aka Methylcobalamin) is a highly bioavailable form of B12 that works synergistically with L-Methylfolate to support brain health, energy, and mood.
Is this product safe if I’m pregnant or breastfeeding?
Check with your doctor first. L-Methylfolate is often recommended during pregnancy, but always confirm with your healthcare provider.
Can this supplement interact with medications?
Yes, particularly antidepressants like SSRIs or antiepileptic drugs. Talk to your healthcare provider before combining them.
Are there any known side effects?
Most people tolerate it well. Rare side effects might include headaches, irritability, or GI discomfort, especially at high doses.
How do I take it — with food or without?
It can be taken with or without food, but some people prefer it with a meal to avoid mild stomach discomfort.
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