I'm nervous about the GLP1 drugs and their side effects because I have several auto-immune issues/ongoing health challenges that I'm not convinced the mainstream drugs won't negatively add to. I've had success with most of the ingredients in other supplements that are included here, so I thought I would give it a go. I'm surprised at how quickly this system worked and how much my "food noise" is quieted. I'll plan to come and update this after I've been on them for longer, but I'm hopeful about the weight loss as it's just much easier to eat better and to eat less.