BioActive Vitamin B2

The bioactive B2 formula with the cofactors your body needs to actually use it — for cellular energy, MTHFR, and methylation.

  1. Body-ready R5P — no conversion required — the activated form of vitamin B2 your cells are ready to use — skipping the step standard riboflavin has to go through*
  2. Three ingredients. Three roles. One complete formula — R5P with magnesium bisglycinate for activation and D-ribose for cellular energy — not R5P alone*
  3. Built for MTHFR, methylation & cellular energy — fuels the 100+ enzymes riboflavin drives across methylation, ATP, nervous system, and antioxidant pathways*
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Most B2 supplements give you basic riboflavin your body still has to convert. BioActive B2 skips the step — delivering R5P (the body-ready form of vitamin B2) alongside the two cofactors your cells need to use it: magnesium bisglycinate for activation and D-ribose for cellular energy.

One complete formula supporting cellular energy, MTHFR and methylation, nervous system function, and antioxidant pathways.

Choose your strength:

  • Daily 100mg R5P — one capsule, foundational everyday support.
  • Clinical 400mg R5P — two capsules, research-level dosing for intensive support.
  • Body-ready B2 — no conversion needed*
  • Supports MTHFR & methylation*
  • Powers cellular energy & nervous system*
  • Riboflavin (Vitamin B2) (as riboflavin-5'-phosphate sodium)
  • Magnesium (as magnesium bisglycinate chelate)
  • D-Ribose

Take 1 capsule daily with food or as directed by a healthcare practitioner.

NOTE: The 400mg Clinical Strength provides enhanced B2 support for those with higher needs.
For daily maintenance, see our 100mg Standard Strength formula.

Active B2 With Absorption Cofactors

Already active R-5-P

Magnesium + D-Ribose cofactors

Formulated for absorption

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Why The Cheapest Vitamin B2 Isn't Actually Cheaper

Form Alone Is Not Enough

Standard B2
(Riboflavin)
R5P Only (Single)
 BioActive B2™
Form
Inactive Form
Active Form
Active Form
Dose of active B2
Varies
10–36 mg
100mg - 400 mg
Matches clinical research dose
Magnesium to support B2 at the cellular level
50 mg
D-Ribose to fuel B2 activation
250 mg
Whole System Approach

A System That Works Together

Three ingredients. Three roles. One complete B2.

R-5-P

The Form
Delivered directly in its active form - no conversion required, so your body puts B2 to work immediately."

Magnesium Bisglycinate

The Activator
The enzyme that activates B2 requires magnesium to function. We use bisglycinate - the form your body absorbs best."

D-Ribose

The Fuel
B2 activation is an energy-dependent process. D-Ribose fuels the cellular machinery that makes it happen.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

What Complete B2 Actually Does

The benefits of body-ready R5P + absorption cofactors*

  • Cellular Energy Production

    Powers 100+ enzymes that keep your cells running*

  • MTHFR & Methylation

    Active B2 is a required cofactor for your MTHFR enzyme*

  • Nervous System Function

    B2 plays a role in healthy nerve function and myelin maintenance*

  • Antioxidant Defense

    Active B2 helps regenerate glutathione, a key part of your body's antioxidant system*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Choose the B2 That is Right For You

BioActive B1 - Daily Optimization

  • Daily B2 support for energy and cellular health
  • MTHFR and methylation support
  • Everyday antioxidant defense
  • Anyone new to R5P or wanting robust daily support

BioActive B2 - Maximum Strength

  • Occasional headache support
  • Anyone following a practitioner's protocol
  • Those who've used lower doses and want stronger support

BioActive Vitamin B2 Over Time

Results build with consistency. Here's what to expect along the way.

1-2 Weeks

Getting Started

Your cells start getting body-ready B2 every day - the form they actually use. Magnesium and D-ribose come along to help your body put it to work. If you notice bright yellow urine, it just means you're getting plenty of B2.*

3 - 4 weeks

Antioxidant Support Kicks In

B2 helps your body defend cells from everyday wear and tear - the kind that comes from stress, exercise, and just being alive. It does this by recharging glutathione, one of your body's top antioxidants.*

5+ Weeks

Full Support, Locked In

This is where it all comes together. Steadier energy through the day. Ongoing antioxidant defense. Support for methylation, nerves, and MTHFR function. Keep taking it daily to stay here.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Meet Our
Science Advisory Board

Our Science Advisory Board brings research, performance science, and nutritional biochemistry expertise to every formula - grounded in published research.

Dr. Will Aguila, MD

“Your best self isn’t something you create— it’s something you uncover when the body is finally given what it truly needs.”

Dr. Nicole Avena, PhD

“Transparency in formulation empowers people to care for their health with confidence.”

Dr. Dan Sullivan, ND

"Remove what's in the way. Provide what's missing. Trust the process."

Built for People Who Read the Label

  • Every Batch Is Third Party Tested

    Every bottle is independently verified and tested for contaminants and heavy metals before it ever reaches you.

  • Quality Standards You Can Trust

    Our formula is vegan, GMO-free, gluten-free, binders-free, uses low FODMAP ingredients and is manufactured in a GMP certified facility.

  • Clinically Studied Ingredients

    We choose every ingredient based on absorption, potency, and published research.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Frequently asked questions

BioActive Vitamin B2™ is Triquetra Health's activated B2 supplement, available in two strengths — Daily Optimization (100mg) and Clinical Strength (400mg). Both deliver the same complete formula: Activated B2 + Absorption Cofactors — body-ready R5P (Riboflavin-5'-Phosphate) enhanced with magnesium bisglycinate and D-ribose.

Most B2 supplements stop at the form. They give you standard riboflavin that has to be converted, or R5P alone at token doses (10–36mg). BioActive B2 completes the formula: the bioactive form your body prefers, plus the cofactors that help your body actually use it. Three ingredients. Three roles. One complete B2.*

Both share the same Activated B2 + Absorption Cofactors formula. The difference is dose and goal.

Daily Optimization (100mg) supports daily cellular energy, MTHFR and methylation pathways, and everyday B2 optimization. At 100mg body-ready R5P, it vastly exceeds the amounts shown to support MTHFR function in research.*

Clinical Strength (400mg) matches the exact dose from the landmark Schoenen 1998 riboflavin study published in Neurology — the reference dose for occasional headache support, over 3–4 months of consistent daily use. It's also our pick for intensive MTHFR support.*

New to B2 or looking for daily optimization? Start with 100mg. Specifically seeking the research-backed dose? Choose Clinical Strength.

R5P (Riboflavin-5'-Phosphate) is the bioactive form of B2 — the same form found naturally in your tissues. Standard riboflavin has to be converted by your body before your cells can use it. R5P skips that conversion step entirely.

No extra conversion step. Just B2 that's ready to work.

But R5P alone isn't the full story. Even body-ready B2 needs cofactor support to complete activation — which is why BioActive B2 pairs R5P with magnesium bisglycinate and D-ribose. The right form, plus what your body needs to actually use it.*

Yes — BioActive B2 supports MTHFR and methylation pathways through its complete cofactor formula.* Your MTHFR enzyme depends on FAD (the active form of B2) to function properly. R5P provides the substrate your body converts to FAD more efficiently than standard riboflavin, and magnesium supports FAD synthetase — the enzyme that activates R5P into FAD.

BioActive B2 pairs naturally with methylfolate (5-MTHF) and methylcobalamin (B12) in methylation protocols. For daily methylation support, Daily Optimization (100mg) is a strong starting point. For intensive MTHFR support, Clinical Strength (400mg) delivers robust FAD substrate for methylation pathways.*

Because body-ready B2 still needs help to be fully activated in your cells — and most B2 supplements leave that gap unfilled.

Your body uses an enzyme called FAD synthetase to convert R5P into FAD (the active cofactor form), and that enzyme requires magnesium to function. Without adequate magnesium, activation slows down. We include magnesium bisglycinate — the superior-absorption form (23.5% vs. 11.8% for magnesium oxide) — so your body has what it needs.

We also include D-ribose to support the cellular energy processes involved in B2 activation. Not just the right form — the complete formula for B2 your body can actually use.*

Take one capsule daily with food if you're using Daily Optimization (100mg), or two capsules daily with food if you're using Clinical Strength (400mg) — ideally with breakfast or your morning meal. Consistency matters more than timing, so take it at the same time each day.

Most people give it 2–3 weeks for cellular energy and general wellness support, and 4–6 weeks of consistent use for MTHFR and methylation support.* For Clinical Strength (400mg), the research timeline for occasional headache support is 3–4 months of consistent daily use (Schoenen 1998).

Individual results vary. Consult your healthca

Yes — BioActive B2 pairs well with most supplements and is especially well-suited for methylation protocols.*

For MTHFR support, it pairs naturally with methylfolate (5-MTHF) and methylcobalamin (B12) — our R5P supports the MTHFR enzyme that activates folate. It's also compatible with CoQ10 for mitochondrial support, omega-3s for cellular health, and vitamin D3+K2 for overall wellness.

Consult your healthcare provider about specific medication interactions or if you have a medical condition.*

Standards without compromise

We prioritize ingredient purity, thoughtful formulation, and rigorous sourcing standards to support quality and consistency in every batch.

Vegan

GMO
free

Gluten
free

Soy
free

GMP
certified

Third-party
tested

Build Your Complete Routine

Warning: If you have a medical condition or are taking medication, contact a physician before taking this supplement. Keep out of reach of children. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

To report a serious adverse event, please contact 844-272-6337.