L-Methylfolate (15 mg) Plus Methyl-B12
L-Methylfolate (15 mg) Plus Methyl-B12
L-Methylfolate (15 mg) Plus Methyl-B12
L-Methylfolate (15 mg) Plus Methyl-B12
L-Methylfolate (15 mg) Plus Methyl-B12
$21.99
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Key Ingredients

  • Folate

  • Vitamin B12

Size / Suggested Use

  • Size: 1 oz - 60 Servings

Product Details

  • Absorbs directly into the bloodstream and requires no processing from the body.
  • Contains the essential Cofactor MethylB12.
  • Supports brain and heart health and contributes to balancing energy, hormones, and mood
L-Methylfolate is the biologically active, bloodstream-ready form of Folate (Vitamin B9). Our formulation provides a maximum strength dose of 15 mg L-Methylfolate. This strength was formulated to support optimal folate levels. The formula also includes a whole serving of Methyl-B12, an essential cofactor to L-Methylfolate. The liquid sublingual form provides enhanced absorption and an enjoyable cherry flavor. It also contributes to the production of neurotransmitters, which are involved in maintaining focus, regulating sleep patterns, providing energy, balancing hormones, and impacting mood. Furthermore, Methylfolate promotes heart health and optimal nerve function.*

Supplement Facts

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Quantity
  • 1-Bottle
  • 2-Bottles
Quantity
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supports optimal
folate levels
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The efficacy of a 15mg dose of l-Methlyfolate was validated in the following study: Hardin A, Baldwin-Sayre C. L-Methylfolate as a Monotherapy for Treatment-Resistant Depression: A Case Study. Integr Med (Encinitas). 2020 Aug;19(4):14-18. PMID: 33132780; PMCID: PMC7572139.
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The Essential B-Vitamin Combo
  • Supports Mood & Cognition*

  • Supports Methylation Issues*

  • Support Heart Health*

  • Supports Pregnancy & Baby Development*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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The Metabolically Active Form of Folate
5 MTHF Form - Bloodstream Ready
L-Methyfolate is the active & bloodstream ready form of Folate (B9). It is immediately absorbed into the bloodstream and does not require processing by the body.

Methyl-B12 Cofactor - Methylation Form
L-Methylfolate cannot do its job in the body without Methyl B12 cofactor because of its role in the methylation process. If L-Methylfolate is the fire, Methyl B12 is the firewood. 
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The quality you deserve
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  • Organic Certififed


  • CGMP Manufacturing


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Warning: If you have a medical condition or are taking medication, contact a physician before taking this supplement. Keep out of reach of children.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
To report a serious adverse event, please contact 844-272-6337.

Frequently Asked Questions

Is this product easy on the stomach?

It is very gentle on the digestive system. For safe measure, if you have a sensitive digestive system you can take it with food.

Is this recommended for kids?

We do not recommend the product for children 12 and younger.

Is this product soy, corn and gluten free?

Yes, it is free of all three.

What are all of the active ingredients?

L-Methyl Folate (vitamin B9) and Methylcobalamin (vitamin B12) are the 2 active ingredients. These are both the methyl B vitamins.

Where are the ingredients sourced from?

All of the ingredients are produced and sourced from the USA.

Customer Reviews

Based on 227 reviews
95%
(215)
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(7)
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K
Kristy P.

L-Methylfolate (15 mg) Plus Methyl-B12

M
Melanie W.
A product that actually works!!!!

I absolutely cannot say enough about the L-Methylfolate 15mg drops!! The effect this has had on my memory and mood are truly amazing. I feel better. I can recall words so much quicker. I remember basic information much easier. I have tried at least 15 different supplements for memory, recall, mood, etc and NONE of them came close to helping like the L-Methylfolate drops have. I never write reviews but for a product like this I have to share and hope others read this and try it. If you have memory or recall issues you have to give it a try!!

N
Nathan M.

Can’t really tell difference

T
Teresa S.
I feel so much better

It helps me so much. I am feeling better now.
Thank you.

B
Bryan T.
Methylation Made Simple

What is methylation? At its core, it’s a biochemical process where a tiny molecule—one carbon and three hydrogens, called a methyl group—gets handed off from one substance to another. Think of it as flipping switches ‘on’ or ‘off’ in your body. When it’s working well, it keeps your systems humming—your heart, your brain, your liver, even your energy levels. It’s behind things like making DNA, producing neurotransmitters like serotonin, and detoxifying your body.
But here’s the catch: for methylation to work, your body needs a key player called SAMe—S-adenosylmethionine. It’s like the universal handyman donating those methyl groups. And to make SAMe, your body relies on a critical B vitamin: active folate, or 5-MTHF. Add in some active B12—methylcobalamin—and you’ve got a powerhouse duo keeping this cycle running smoothly.

Now, here’s where it gets interesting. About 60% of us have a genetic quirk—something called an MTHFR mutation—that makes it harder to turn regular folic acid into the active 5-MTHF our bodies need. If that switch is off, SAMe production slows down, and suddenly, your body struggles to make things like glutathione for detox, melatonin for sleep, or even nitric oxide for healthy blood flow."
That’s why I’m excited about this little dropper from Trigquetra. It’s a liquid blend of L-methyl folate—already in that active 5-MTHF form—plus methylcobalamin, the active version of B12. No conversion needed. A dropperful on or under your tongue is like giving your body the tools it’s been asking for, especially if you’re one of those 60% with that genetic hiccup. A few drops a day, and you’re supporting your methylation cycle—your heart, your brain, your energy—all without another pill to swallow.

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