My daughter had a lot of other like health issues that we couldn't figure out what was going on. We found out she had this gene mutation and worked hard towards cleaning up her diet and giving her the supplements she needs. She can tell a difference in how clear she is thinking and how much energy she has when she takes this versus when she forgets. We just threw one drop two times a day. It's very potent. If she does several drops, it makes her kidneys hurt. So we don't even do the full dose but it is right. I'm so glad they have the drops too instead of just the capsules because she wouldn't be able to take those, whereas these are perfect for her.