Healthy methylation plays a role in many everyday functions:
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Methylated Folate: A Nutrient Form Some People Prefer for Genetic Support*
Certain MTHFR gene variations may affect how the body processes synthetic folic acid. Methylated forms like 5-MTHF can offer a more direct form of folate support.
Methylated vitamins provide folate in a body-ready form, supporting bioavailability and cellular use.*
Up to 40% of people may carry a common MTHFR gene variant.*
How L-Methylfolate Works in the Body
Supports neurotransmitters like serotonin, dopamine & norepinephrine.*
Supports red blood cells production and detox in the body.*
Helps your homocysteine levels stay in check which is vital for heart and brain health.*
Reasons to Love Our L-Methylfolate
Designed for Efficient Absorption*
No Conversion Required - Body-Ready Form*
Enhanced with B12*
Clinically Validated Doses
7.5 mg L-Methylfolate
L-Methylfolate is the active & bloodstream ready form of Folate (B9) immediately absorbed into the bloodstream without requiring processing by the body.
750 mcg Methyl B12
L-Methyfolate cannot do its job in the body without Methyl B12. If L-Methyfolate is the fire, think of Methyl B12 as the firewood.
See how L-Methylfolate Helped Others!
* These testimonials represent individual experiences. Participants received free product samples and were compensated for their time, but their opinions are entirely their own and were not influenced by our team. Individual results may vary.
Body-Ready Nutrients in One Easy Dose
Supports Mood & Cognition*
Supports Healthy Methylation*
Supports Heart Health*
Supports Nerve Cognition*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Which dose is right for you?
1 mg Light
Supplementation
Best For: This is a starting dose for general wellness or individuals who want to support methylation.
Best For: Those looking for a higher dose of folate to support advanced nutritional needs or personalized wellness goals, as recommended by a healthcare professional.*
Some individuals may begin to notice support for mental clarity, mood balance, and energy. This is also when nutritional support for red blood cell formation and homocysteine metabolism may begin.*
Weeks 4-8: Noticeable Support*
Neurotransmitter production for the ‘feel good’ hormones like serotonin & dopamine goes up which can help with an improvement in mood and a reduction in symptoms of anxiety.*
Month 3-6: Ongoing Support*
Some individuals may notice more consistent energy levels and support for healthy eating patterns. Users have also shared feeling more in tune with their overall wellness goals and daily routines.*
Disclaimer: Individual results vary. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
"As a health researcher, I view L-Methylfolate as an essential nutrient for neurological, emotional, and metabolic balance—especially in individuals with genetic variants like MTHFR. Triquetra’s L-Methylfolate line stands out for its clinically relevant dosing, exceptional purity, and highly bioavailable formulas, with options tailored for both adults and children. It’s a science-backed choice for those seeking therapeutic efficacy and uncompromising quality."
Adriano Zanardi da Silva, M.Sc., Ph.D
Quality Standards You Can Trust
Warning: If you have a medical condition or are taking medication, contact a physician before taking this supplement. Keep out of reach of children.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
To report a serious adverse event, please contact 844-272-6337.
What is L-Methylfolate and how is it different from folic acid?
L-Methylfolate is the active form of folate that your body can use immediately. Folic acid needs to be converted—and some people can’t do that well because of genetic mutations like MTHFR.
What is Methyl B12 and why is it paired with L-Methylfolate?
Methyl B12 (aka Methylcobalamin) is a highly bioavailable form of B12 that works synergistically with L-Methylfolate to support brain health, energy, and mood.
Is this product safe if I’m pregnant or breastfeeding?
Check with your doctor first. L-Methylfolate is often recommended during pregnancy, but always confirm with your healthcare provider.
Can this supplement interact with medications?
It is possible L-Methylfolate may interact with certain medications. It is always best to check with a healthcare provider before starting any supplements.
Are there any known side effects?
Most people tolerate it well. If you feel like you are sensitive to higher doses, you can work your way up to the full dose over time.
How do I take it — with food or without?
It can be taken with or without food, but some people prefer it with a meal to avoid mild stomach discomfort.
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