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Your labs were “normal,” but your symptoms weren’t. 
You did the research and found the gene.
You had a methylation problem. 
Here's the methylfolate that matches the research.
You had a methylation problem. 
Here's the methylfolate that matches the research.
SHOP NOW
Triquetra L-Methylfolate 15 mg capsules with 5-MTHF active folate and methyl B12 for methylation, brain, mood, heart and nerve support
Triquetra L-Methylfolate 15 mg liquid drops with 5-MTHF active folate and methyl B12 for methylation, brain, mood, heart and nerve support
L-Methylfolate (15 mg) Plus Methyl B12 (CS)
L-Methylfolate (15 mg) Plus Methyl B12 (CS)
L-Methylfolate (15 mg) Plus Methyl B12 (CS)
L-Methylfolate (15 mg) Plus Methyl B12 (CS)
Triquetra L-Methylfolate 15 mg capsules with 5-MTHF active folate and methyl B12 for methylation, brain, mood, heart and nerve support
Triquetra L-Methylfolate 15 mg liquid drops with 5-MTHF active folate and methyl B12 for methylation, brain, mood, heart and nerve support
L-Methylfolate (15 mg) Plus Methyl B12 (CS)
L-Methylfolate (15 mg) Plus Methyl B12 (CS)
L-Methylfolate (15 mg) Plus Methyl B12 (CS)
L-Methylfolate (15 mg) Plus Methyl B12 (CS)
Key Ingredients

Two finished forms. Both ready the moment they hit your bloodstream.

🧬 L-Methylfolate (L-5-MTHF Calcium Salt) — 15 mg

The active, finished form of folate. No conversion required. 10× more absorbable than folic acid in MTHFR-variant cells.

💊 Methylcobalamin (Active B12) — 1,000 mcg

The bioidentical, pre-activated form of B12 your body uses directly. Supports the methylation cycle, healthy nerve function, and steady cellular energy.

Health Benefits

What complete methylation support means for how you feel and perform.

Mood support

Folate supports the body's natural production of key neurotransmitters that influence mood, including serotonin, dopamine, and norepinephrine.

Mental focus and cognitive function

Folate supports the brain's energy metabolism and the cellular pathways behind clear thinking.

Cellular energy

Methylation is foundational to mitochondrial function and the body's natural ATP production.

Hormone metabolism

Folate supports the methylation pathways involved in the body's natural processing of hormones.

Healthy inflammatory response

Methylation is involved in the body's normal inflammatory signaling pathways.

Heart health

Folate supports the body's normal homocysteine metabolism, which is involved in healthy cardiovascular function.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ideal For

Who this formula is built for.

The mom running on fumes.

Carrying mental load, snapping at people you love, and never quite catching up on rest — even when you sleep.

The high-performer who can't focus anymore.

You used to think clearly. Now the words don't come, the afternoons drag, and you wonder when your brain stopped working the way it used to.

The person who's tried everything.

Folic acid, B-complex, multivitamins, adaptogens — none of it moved the needle. You're wondering if you're broken or if you've just been taking the wrong thing.

The one whose family has "the mental health stuff."

Anxiety, depression, mood swings, ADHD — patterns that run in the family. You've started to wonder if there's a common thread.

The clean eater who still feels off.

You eat the leafy greens. You take the prenatal. You do the cold plunge. And somehow your energy, mood, and focus still don't match the effort.

Anyone who's been told they have an MTHFR variant.

Or anyone who suspects they might. (1 in 2 adults carry it. Most never get tested.)

Supplement Facts

Servings Per Container: 60

Ingredient Amount %DV
Folate (as L-Methylfolate, L-5-MTHF Calcium Salt) 15 mg DFE
(8,824 mcg)		 3,750%
Vitamin B12 (as Methylcobalamin) 1,000 mcg 41,667%

L-Methylfolate ™— Active 5-MTHF + Methyl B12

America's #1 methylfolate. 15 mg of active 5-MTHF paired with methyl B12 — the two pre-converted forms your body actually uses for steady mood, sharp focus, and lasting energy. No conversion required.

  • Already activated. Already absorbable. Most folate is folic acid — your body has to convert it. 5-MTHF is the active form, ready the moment it hits your bloodstream.

  • Folate and B12 work as a pair. Active folate without active B12 stalls. This formula delivers both in their finished forms.

  • A clinical 15 mg dose. Not a sprinkle. The dose published research actually uses.

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#1 Best-Selling Methylfolate on Amazon
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  • 30-day guarantee

  • 3rd-Party Tested

  • FSA/HSA Eligible

  • FREE shipping on every subscription order

The 30-Day Feel-the-Difference Promise.

If you don't feel the lift in mood, focus, or energy your research told you a real clinical dose should deliver — send the bottle back for a full refund.
Key Ingredients

Two finished forms. Both ready the moment they hit your bloodstream.

🧬 L-Methylfolate (L-5-MTHF Calcium Salt) — 15 mg

The active, finished form of folate. No conversion required. 10× more absorbable than folic acid in MTHFR-variant cells.

💊 Methylcobalamin (Active B12) — 1,000 mcg

The bioidentical, pre-activated form of B12 your body uses directly. Supports the methylation cycle, healthy nerve function, and steady cellular energy.

Health Benefits

What complete methylation support means for how you feel and perform.

Mood support

Folate supports the body's natural production of key neurotransmitters that influence mood, including serotonin, dopamine, and norepinephrine.

Mental focus and cognitive function

Folate supports the brain's energy metabolism and the cellular pathways behind clear thinking.

Cellular energy

Methylation is foundational to mitochondrial function and the body's natural ATP production.

Hormone metabolism

Folate supports the methylation pathways involved in the body's natural processing of hormones.

Healthy inflammatory response

Methylation is involved in the body's normal inflammatory signaling pathways.

Heart health

Folate supports the body's normal homocysteine metabolism, which is involved in healthy cardiovascular function.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ideal For

Who this formula is built for.

The mom running on fumes.

Carrying mental load, snapping at people you love, and never quite catching up on rest — even when you sleep.

The high-performer who can't focus anymore.

You used to think clearly. Now the words don't come, the afternoons drag, and you wonder when your brain stopped working the way it used to.

The person who's tried everything.

Folic acid, B-complex, multivitamins, adaptogens — none of it moved the needle. You're wondering if you're broken or if you've just been taking the wrong thing.

The one whose family has "the mental health stuff."

Anxiety, depression, mood swings, ADHD — patterns that run in the family. You've started to wonder if there's a common thread.

The clean eater who still feels off.

You eat the leafy greens. You take the prenatal. You do the cold plunge. And somehow your energy, mood, and focus still don't match the effort.

Anyone who's been told they have an MTHFR variant.

Or anyone who suspects they might. (1 in 2 adults carry it. Most never get tested.)

Supplement Facts

Servings Per Container: 60

Ingredient Amount %DV
Folate (as L-Methylfolate, L-5-MTHF Calcium Salt) 15 mg DFE
(8,824 mcg)		 3,750%
Vitamin B12 (as Methylcobalamin) 1,000 mcg 41,667%
America's #1 Selling L-Methylfolate
Over 5 Million Bottles Sold
GMP Manufactured
3rd-Party Tested
Clinically Dosed Formula
No Proprietary Blends
Formulated With Science Advisors
HSA/FSA Eligible
Backed by the 30 Day Feel-the-Difference Promise
Folic Acid The Precursor
MTHFR The Bottleneck
L-Methylfolate The Active Form

See How L-Methylfolate Helped Others!

* These testimonials represent individual experiences. Participants received free product samples and were compensated for their time, but their opinions are entirely their own and were not influenced by our team. Individual results may vary. 

Hear From Our Experts

Hear From 
Our Experts

Also available for kids

Gentle, easy-to-use drops for younger needs.

KIDS L-Methylfolate

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Triquetra Flora Biome liquid probiotic with prebiotics and postbiotics for gut health and microbiome supportTriquetra Flora Biome fermented liquid probiotic with herbal prebiotics and live cultures for gut health

Flora Biome™ Live Probiotic

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Triquetra L-Methylfolate 15 mg liquid drops with 5-MTHF active folate and methyl B12 for methylation, brain, mood, heart and nerve supportMan using Triquetra L-Methylfolate 15 mg liquid drops with 5-MTHF active folate and methyl B12 sublingual methylation support supplement

L-Methylfolate (15 mg) Plus Methyl-B12

$21.99
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Triquetra L-Methylfolate 15 mg capsules with 5-MTHF active folate and methyl B12 for methylation, brain, mood, heart and nerve supportWoman holding Triquetra L-Methylfolate 15 mg capsules with 5-MTHF folate and methyl B12 for methylation and cellular health support

L-Methylfolate (15 mg) Plus Methyl B12 Capsules

$21.99
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Triquetra L-Methylfolate 1 mg liquid drops with 5-MTHF active folate and methyl B12 for methylation, brain, mood, heart and nerve supportMan using Triquetra L-Methylfolate 1 mg liquid drops with 5-MTHF active folate and methyl B12 for daily methylation support

L-Methylfolate (1mg) Plus Methyl-B12

$21.99
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Triquetra GLP-Activate natural GLP-1 support supplement bottle and box for appetite control, metabolic support, and weight managementGLP-Activate supplement supporting natural GLP-1 pathways for healthy appetite control, metabolic function, and weight management with daily use

GLP-Activate: Hunger & Metabolism Support

$44.99
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Triquetra Kids L-Methylfolate liquid with 5-MTHF active folate and methyl B12 for brain development, mood and behavior support in childrenKids L-Methylfolate liquid with 5-MTHF folate and methyl B12 for brain development, methylation support and adjustable dosing for children

Kids Methylfolate Plus B12 Cofactor

$18.99
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Frequently Asked Questions

Is this product safe if I'm pregnant or breastfeeding?
L-Methylfolate is the form many practitioners recommend during pregnancy and breastfeeding — but every pregnancy is different. Please share this product with your OB/GYN or midwife before starting, especially if you are taking a separate prenatal vitamin.

Are there any known side effects?
Most people tolerate L-Methylfolate well. A small number of people new to methylation support report transient symptoms in the first week (mild headache, irritability, or increased energy at night). Lowering the dose or taking it earlier in the day usually resolves it. If symptoms persist, stop the product and consult your practitioner.

Can this supplement interact with medications?
L-Methylfolate can interact with certain medications, including methotrexate, anticonvulsants, and some SSRIs. If you are currently on a prescription, please discuss with your prescribing provider before starting any new methylation support.

What is L-Methylfolate and how is it different from folic acid?
Folic acid is a synthetic form of folate that your liver has to convert into the active form (5-MTHF) before your body can use it. L-Methylfolate is already in that active form — no conversion needed. For people with a common MTHFR gene variation, that conversion is impaired, which is why an active 5-MTHF supplement is often a better fit.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.