L-Methylfolate (7.5mg) Plus Methyl-B12

Methyl_Folate_Boxt_and_Bottle_with_frontrowMD

do you Prefer Capsules?

Shop Now

L-Methylfolate (7.5mg) Plus Methyl-B12

Key Ingredients

Folate
Vitamin B12

Size / Suggested Use

Size: 120 servings - Berry Flavor

Product Details

L-Methylfolate provides a potent, bloodstream-ready dose of 7.5mg of the most active form of Folate in the 5-MTHF calcium salt form.
Created with Methylcobalamin B12 to help support heart health and nerve function by regulating healthy homocysteine levels and nitric oxide production.
A powerful and reliable supplement to improve your mood, energy, concentration, and sleep.

Our professional strength L-Methylfolate and Methyl B12, is a methylation support product designed based on clinical research. Each dose provides 7.5mg L-Methylfolate in the 5-MTHF calcium salt form plus 750 mcg of Methyl B12. L-Methylfolate is the active form of Folate and is bloodstream ready. This formulation was designed to support health methylation, mood, and brain health.

Supplement Facts

Quantity

1-Bottle

2-Bottles

3-Bottles

6-Bottles

Purchase Type

Frequency

Healthy methylation plays a role in many everyday functions:

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Methylated Folate: A Nutrient Form Some People Prefer for Genetic Support*

Certain MTHFR gene variations may affect how the body processes synthetic folic acid. Methylated forms like 5-MTHF can offer a more direct form of folate support.

Methylated vitamins provide folate in a body-ready form, supporting bioavailability and cellular use.*

Up to 40% of people may carry a common MTHFR gene variant.*

Why You’ll Love Our L-Methylfolate

Bloodstream Ready L-Methyfolate*

Designed for Efficient Absorption*

No Conversion Required - Body-Ready Form*

Enhanced with B12*

How L-Methylfolate Works in the Body

Supports neurotransmitters like serotonin, dopamine & norepinephrine.*

Supports red blood cells production and detox in the body.*

Helps your homocysteine levels stay in check which is vital for heart and brain health.*

Body-Ready Nutrients in One Easy Dose

Supports Mood & Cognition*

Supports Healthy Methylation*

Supports Heart Health*

Supports Nerve Cognition*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

See how L-Methylfolate Helped Others!

* These testimonials represent individual experiences. Participants received free product samples and were compensated for their time, but their opinions are entirely their own and were not influenced by our team. Individual results may vary.

How to Take L-Methyfolate

1. Shake well before use.

2. Take 5 droplets directly under tongue

OR mix 5 droplets into your favorite drinks, smoothies or water.

Know your supplement

Our drops are a deep, rich burgundy shade. Please be cautious of counterfeit products that may differ in color or quality. To ensure you receive a genuine product, only purchase from our official websites or stores.

Which dose is right for you?

1 mg Light

Supplementation

Best For: This is a starting dose for general wellness or individuals who want to support methylation.

Learn More

7.5 mg Moderate Supplementation

Best For: Individuals seeking a higher level of methylated folate to support folate metabolism and cellular function.*

Learn More

15 mg High

Supplementation

Best For: Those looking for a higher dose of folate to support advanced nutritional needs or personalized wellness goals, as recommended by a healthcare professional.*

Learn More

Genetic Wellness Support Starts Early

Daily Nutritional Folate support with

KIDS L-Methylfolate

Shop Now

Results Over Time

3-7 Days: Gradual Support*

Some individuals may begin to notice support for mental clarity, mood balance, and energy. This is also when nutritional support for red blood cell formation and homocysteine metabolism may begin.*

Weeks 4-8: Noticeable Support*

Neurotransmitter production for the ‘feel good’ hormones like serotonin & dopamine goes up which can help with an improvement in mood and a reduction in symptoms of anxiety.*

Month 3-6: Ongoing Support*

Some individuals may notice more consistent energy levels and support for healthy eating patterns. Users have also shared feeling more in tune with their overall wellness goals and daily routines.*

Disclaimer: Individual results vary. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Shop Now

Hear From Our Experts

"As a health researcher, I view L-Methylfolate as an essential nutrient for neurological, emotional, and metabolic balance—especially in individuals with genetic variants like MTHFR. Triquetra’s L-Methylfolate line stands out for its clinically relevant dosing, exceptional purity, and highly bioavailable formulas, with options tailored for both adults and children. It’s a science-backed choice for those seeking therapeutic efficacy and uncompromising quality."

Adriano Zanardi da Silva, M.Sc., Ph.D

Quality Standards You Can Trust

Warning: If you have a medical condition or are taking medication, contact a physician before taking this supplement. Keep out of reach of children.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

To report a serious adverse event, please contact 844-272-6337.

Frequently Asked Questions

What is L-Methylfolate and how is it different from folic acid?

L-Methylfolate is the active form of folate that your body can use immediately. Folic acid needs to be converted—and some people can’t do that well because of genetic mutations like MTHFR.

What is Methyl B12 and why is it paired with L-Methylfolate?

Methyl B12 (aka Methylcobalamin) is a highly bioavailable form of B12 that works synergistically with L-Methylfolate to support brain health, energy, and mood.

Is this product safe if I’m pregnant or breastfeeding?

Check with your doctor first. L-Methylfolate is often recommended during pregnancy, but always confirm with your healthcare provider.

Can this supplement interact with medications?

It is possible L-Methylfolate may interact with certain medications. It is always best to check with a healthcare provider before starting any supplements.

Are there any known side effects?

Most people tolerate it well. If you feel like you are sensitive to higher doses, you can work your way up to the full dose over time.

How do I take it — with food or without?

It can be taken with or without food, but some people prefer it with a meal to avoid mild stomach discomfort.

Ordered this for the methyfolate, overjoyed with the B-12!

I’m a few weeks into taking this supplement. Around a week after I started it, I woke up one morning will tingling in my arms and toes. It almost fell like they were falling asleep, only instead of losing sensation, I was gaining it! The tips of my toes were numb since I was 18 (I’m 49) and the outsides of my arms for about 10 years. The doctor told me it was carpal tunnel… now I’m thinking I’ve been b-12 deficient all this time! The tingling resolved within a day or so, and I’m enjoying feeling my extremities again! Wish I knew I needed methylated B-12 years ago!!!!

Pediatrician recommended for daughter

My daughter’s pediatrician recommended we get this she recently had genetic testing that showed the MTHFR and my daughter is not a fan of taking vitamins. She has a lot of allergies and a sensitive stomach but since this is sublingual, she’s been on it for over a month and she absolutely loves it.

MTHFR

I haven’t got my labs yet on my MTHFR.. but I can tell it’s working! I have high homocysteine and I need methylated folate and B12. I will continue to use this product!

Works great

I keep coming back for it

There’s a noticeable difference when I’m not taking it. I have a hard time absorbing B vitamins (i.e. thin and brittle nails, dry hair and skin). I need methylated forms and this is the easiest in my opinion.

1 2

Key Ingredients

Size / Suggested Use

Product Details

Supplement Facts

Why You’ll Love Our L-Methylfolate

How L-Methylfolate Works in the Body

Body-Ready Nutrients in One Easy Dose

See how L-Methylfolate Helped Others!

* These testimonials represent individual experiences. Participants received free product samples and were compensated for their time, but their opinions are entirely their own and were not influenced by our team. Individual results may vary.

How to Take L-Methyfolate

Which dose is right for you?

3-7 Days: Gradual Support*

Weeks 4-8: Noticeable Support*

Month 3-6: Ongoing Support*

Hear From Our Experts

Quality Standards You Can Trust

Frequently Asked Questions

What is L-Methylfolate and how is it different from folic acid?

What is Methyl B12 and why is it paired with L-Methylfolate?

Is this product safe if I’m pregnant or breastfeeding?

Can this supplement interact with medications?

Are there any known side effects?

How do I take it — with food or without?

Customer Reviews

Explore

Shop

Sign up and never miss brand exclusives and updates!

Sign up and never miss brand exclusives and updates!

Sign up and never miss brand
exclusives and updates!