L-Methylfolate 15mg

Choose your form

💊 Capsules

💧 Liquid

L-Methylfolate (15 mg) Plus Methyl B12 (CS)

Clinically dosed · clean label

Finally found the answer.
Now get the one that doesn't cut corners.

15mg active L-Methylfolate + Methyl B12 — formulated to support healthy mood, energy, focus, and methylation.*

L-Methylfolate (15 mg) Plus Methyl B12

2oz bottle · ~60 servings · FSA/HSA eligible

Select Your Plan

30-day guarantee
FSA/HSA
Third-Party Tested

Clean Label Project Purity Award
Third-party tested
No folic acid · no fillers
15mg 5-MTHF · Clinical dose

Clean Label Project Purity Award
Third-party tested
No folic acid · no fillers
15mg 5-MTHF · Clinical dose

For people who've been doing their research

Maybe a doctor mentioned MTHFR. Maybe you found it yourself. Either way, you've learned that not all folate is the same.
You've probably tried things that didn't fully work — B-complexes, multivitamins, supplements that helped a little but weren't quite the thing. The issue is usually dose and form.
You're not looking for a generic option. You're looking for the one that's actually formulated correctly.

This is it — 15mg of active 5-MTHF, the clinical dose, clean label, purity-tested, paired with the Methyl B12 your body needs to actually run the methylation cycle.*

"50 years wondering why I was so different. I feel like I've healed 2 years worth in 2 months."

— Todd T.

Verified Triquetra Customer

"After decades of trying different medicines for moods, a blood test revealed I needed methylfolate. I wish I had known this decades ago."

— Renee B.

Verified Triquetra Customer

*Customer testimonials may have been edited for clarity. All testimonials reflect genuine customer experiences.

Choose your form

Same clinical dose. Different delivery.

Both contain the same clinical 15mg dose of active 5-MTHF.

How formulations compare

Most brands don't check all these boxes

Feature	Triquetra 15mg	Generic B-complex	Most "methylated"
Bioactive 5-MTHF form	✓	✗	✓
Therapeutic dose (≥7.5mg)	✓	✗	✗
Methyl B12 included	✓	−	−
Third-party purity tested	✓	−	−
No folic acid in formula	✓	✗	−

− = varies by brand. General category comparisons only.

What to expect

Results over time*

Individual results vary. Patterns shared by hundreds of customers.*

Days 3-7:

Early signals*
Subtle shifts in mental clarity and energy as nutritional support begins.*

Weeks 2–4:

Mood & focus*

Neurotransmitter support for serotonin and dopamine may begin to stabilize.*

Months 3–6:

Sustained support*

Consistent energy, better sleep, and the sense of being present again.*

Days 3–7:

Early signals*

Subtle shifts in mental clarity and energy as nutritional support begins.*

Weeks 2–4:

Mood & focus*

Neurotransmitter support for serotonin and dopamine may begin to stabilize.*

Months 3–6:

Sustained support*

Consistent energy, better sleep, and the sense of being present again.*

⦿ Days 3-7:

Early signals*
Subtle shifts in mental clarity and energy as nutritional support begins.*

⦿ Weeks 2–4:

Mood & focus*
Neurotransmitter support for serotonin and dopamine may begin to stabilize.*

⦿ Months 3–6:

Sustained support*

Consistent energy, better sleep, and the sense of being present again.*

From our community

768 reviews ★★★★★ 4.85

Thuy L.

✓ Verified Triquetra Customer · 07/17/2025

Compound heterozygous MTHFR — difference within a week

"I have compound heterozygous MTHFR. I noticed a difference within a week. Less anxious, calmer, and more aware."

Debra Y.

✓ Verified Triquetra Customer · 01/16/2026

Did the research. Chose Triquetra.

"For years a pharmacy charged me $195 for a 3-month supply. After a lot of research, Triquetra is top quality at a fraction of the price."

Kim C.

✓ Verified Triquetra Customer · 11/30/2025

ADHD + MTHFR. Finally steady.

"Prescriptions just left me sweaty and gave me palpitations. After finding out I had MTHFR, I tried this — and feel a steadiness in the direction of my ship now."

Todd T.

✓ Verified Triquetra Customer · 08/04/2024

50 years. 2 months. Changed.

"50 years wondering why I was so different. I feel like I've healed 2 years in 2 months."

*Customer testimonials may have been edited for clarity. All testimonials reflect genuine customer experiences.

Expert perspective

Adriano Zanardi da Silva, M.Sc., Ph.D.

Health researcher · Nutrition & Genetics

"Triquetra's L-Methylfolate line stands out for clinically relevant dosing, exceptional purity, and highly bioavailable formulas — a science-backed choice for those who won't compromise on quality."

Common questions

FAQ

Capsules or liquid drops — which is better?

Both contain the same 15mg clinical dose of 5-MTHF. Liquid drops are sublingual (absorbed under the tongue) for potentially faster uptake, and include 1000mcg Methyl B12. Capsules include 500mcg Methyl B12 and are easier to fit into a daily routine. It's a preference-based choice — not a quality difference.

Why 15mg specifically?

General folate support doses run 400mcg–1mg. Research on MTHFR support and therapeutic methylation typically uses 7.5–15mg. We offer all three dose levels (1mg, 7.5mg, 15mg) — discuss with your provider what's right for your situation.

Why is Methyl B12 in the formula?

Methylfolate and methylcobalamin (Methyl B12) are co-dependent in the methylation cycle. 5-MTHF can't complete its role without B12 as a co-factor. Most underdosed methylfolate products leave this out entirely.

Are there any known side effects?

Most people tolerate it well. Some sensitive individuals experience mild headaches when starting at higher doses — typically resolved by starting lower and titrating up. If you're on SSRIs or other medications, consult your provider before starting.

What does "clean label" actually mean here?

No unnecessary binders, fillers, artificial flow agents, or synthetic dyes. Third-party tested for purity and potency — the Purity Award reflects that standard. What's on the label is what's in the capsule, nothing added.

Is this safe during pregnancy?

Folate is essential during pregnancy and 5-MTHF is the bioavailable form many practitioners recommend over folic acid, especially for those with MTHFR variants. Always consult your OB-GYN before changing supplements during pregnancy.

L-Methylfolate (15 mg) Plus Methyl B12

From $18.69/mo with subscription

Shop Now

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results vary. Testimonials represent individual experiences and were not influenced by the Triquetra team. Always consult a qualified healthcare provider before starting any new supplement.

Finally found the answer. Now get the one that doesn't cut corners.

15mg active L-Methylfolate + Methyl B12 — formulated to support healthy mood, energy, focus, and methylation.*

2oz bottle · ~60 servings · FSA/HSA eligible

Select Your Plan

For people who've been doing their research

"50 years wondering why I was so different. I feel like I've healed 2 years worth in 2 months."

— Todd T.

Verified Triquetra Customer

"After decades of trying different medicines for moods, a blood test revealed I needed methylfolate. I wish I had known this decades ago."

— Renee B.

Verified Triquetra Customer

*Customer testimonials may have been edited for clarity. All testimonials reflect genuine customer experiences.

Same clinical dose. Different delivery.

Once daily. Easy to fit into any routine. 60 servings per bottle.

Sublingual for faster absorption. Natural berry flavor. No pills.

Both contain the same clinical 15mg dose of active 5-MTHF.

Most brands don't check all these boxes

− = varies by brand. General category comparisons only.

Results over time*

Individual results vary. Patterns shared by hundreds of customers.*

Days 3-7:

Weeks 2–4:

Months 3–6:

⦿ Days 3-7:

⦿ Weeks 2–4:

⦿ Months 3–6:

768 reviews ★★★★★ 4.85

Thuy L.

✓ Verified Triquetra Customer · 07/17/2025

Compound heterozygous MTHFR — difference within a week

"I have compound heterozygous MTHFR. I noticed a difference within a week. Less anxious, calmer, and more aware."

Debra Y.

✓ Verified Triquetra Customer · 01/16/2026

Did the research. Chose Triquetra.

"For years a pharmacy charged me $195 for a 3-month supply. After a lot of research, Triquetra is top quality at a fraction of the price."

Kim C.

✓ Verified Triquetra Customer · 11/30/2025

ADHD + MTHFR. Finally steady.

"Prescriptions just left me sweaty and gave me palpitations. After finding out I had MTHFR, I tried this — and feel a steadiness in the direction of my ship now."

Todd T.

✓ Verified Triquetra Customer · 08/04/2024

50 years. 2 months. Changed.

"50 years wondering why I was so different. I feel like I've healed 2 years in 2 months."

*Customer testimonials may have been edited for clarity. All testimonials reflect genuine customer experiences.

Adriano Zanardi da Silva, M.Sc., Ph.D.

Health researcher · Nutrition & Genetics

"Triquetra's L-Methylfolate line stands out for clinically relevant dosing, exceptional purity, and highly bioavailable formulas — a science-backed choice for those who won't compromise on quality."

Flora Biome™ Live Probiotic